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Irbinitinib is an oral, potent, selective, reversible and ATP-competitive small-molecule inhibitor of ErbB-2 (also called HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively in cell-based assays, showing ~500-fold selective for HER2 vs EGFR. It has potential antineoplastic activity.
CAS:937263-43-9
Molecular Formula:C26H24N8O2
Qualifications:GMP Evaluate Report
File:MOA DMF
Standard:In house
Irbinitinib is an oral, potent, selective, reversible and ATP-competitive small-molecule inhibitor of ErbB-2 (also called HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively in cell-based assays, showing ~500-fold selective for HER2 vs EGFR. It has potential antineoplastic activity.
CAS:937263-43-9
Molecular Formula:C26H24N8O2
Qualifications:GMP Evaluate Report
File:MOA DMF
Standard:In house